Organic Analysis Article Review

Description

Please write an analysis on the article attached. In this analysis, answer the following questions. The one citation I requested must be the article I attached. Please include mechanism screenshots throughout analysis when necessary, but does not count towards the 4 pages requested. Mechanisms can be screenshotted or drawn, whatever is better for you. 1.     Why is there interest in the synthesis of (S)-(-)-3-Butylphthalide and chiral 3-substituted phthalide stuctures? Why was this synthesis different from previous total syntheses?   2.     The article describes a three-step synthesis of (S)-(-)-3-Butylphthalide (1a) shown in Scheme 2. Draw and/or discuss mechanisms for each reactions to form compounds 2j, 6, and 1a.   3.     The article includes a procedure of the three steps in the synthesis of (S)-(-)-3-Butylphthalide (1a). Use the sequence to synthesize compounds 2j, 6, and 1a. Make a list of all the reagents and describe any hazards from their Safety Data Sheets or from GHS labelling. How would you protect yourself while handling these reagents?   4.     The 1H NMR is recorded for (S)-(-)-3-Butylphthalide (1a) at the end of the experimental section. Draw the structure of compound 1a and label all NMR signals with the corresponding hydrogens in the molecule.   5.     Convert the final experimental method of compound 1a to a detailed procedure. Assume you were writing this procedure to be completed in a CHM 227 lab experiment. Include specifics such as glassware, heat sources and appropriate amounts.